Despite several more years as one of the world's best players, the 2003 US Open title would remain his only Grand Slam triumph.
He is the most recent North American male player to win a Grand Slam singles event, reach the top ranking, and claim the year-end world number one ranking (2003).
His coach, Tarik Benhabiles, talked him into giving tennis four more months of undivided attention. Roddick and the Moroccan battled for five hours, with the fifth set (21–19 in favor of Roddick) at the time the longest fifth set in a Grand Slam tournament during the open era, at 2 hours and 23 minutes. Roddick lost his singles match against Rafael Nadal, who would in the following year win the French Open. Roddick motioned to the umpire, pointing to the clear ball mark on the clay indicating that the ball was in, and the call was consequently changed. At the French Open, Roddick lost to unseeded Argentine José Acasuso in the second round, and at Wimbledon, Roddick lost to Federer in the final for the second consecutive year. 3 Lleyton Hewitt at the Masters Series tournament in Cincinnati. At the Grand Prix de Tennis de Lyon, Roddick defeated Gaël Monfils to wrap up a tournament without losing a set or getting his serve broken.
Despite a lackluster French Open, Roddick enjoyed success in the United Kingdom by winning Queen's Club, beating World No. Towards the end of 2004, Roddick fired his coach of 18 months, Brad Gilbert, and hired assistant Davis Cup coach Dean Goldfine. Roddick's first ATP event of the year was the Australian Open.
Reaching the final, however, enabled Roddick to overtake Nikolay Davydenko for the world No.
3 position, his first week inside the top three since March 6, 2006.
Roddick won his quarterfinal match against fellow American Mardy Fish. 1 Federer, who defeated him in straight sets, making his head-to-head record against Federer 1–13.Roddick entered the 2007 Australian Open as the sixth seed.In his first-round match, he lost a marathon first-set tiebreak 20–18, but eventually won the match in four sets against wild card Jo-Wilfried Tsonga from France.His resurgence finally came at the Cincinnati Masters, where he won the event by defeating Juan Carlos Ferrero in the final, making this the first masters event he won since 2004.At the US Open, Roddick easily won his first two matches against Florent Serra and Kristian Pless.